2018

Martin L, Derwall M, Al Zoubi S, Zechendorf E, Reuter DA, Thiemermann C, Schuerholz T. THE SEPTIC HEART Current Understanding of Molecular Mechanisms and Clinical Implications. Chest. 2018. doi: 10.1016/j.chest.2018.08.1037

Yamada N, Martin LB, Zechendorf E, Purvis GSD, Chiazza F, Varrone B, Collino M, Shepherd J, Heinbockel L, Gutsmann T, Correa W, Brandenburg K, Marx G, Schuerholz T, Brohi K, Thiemermann C. Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Ann Surg. 2018; 268: 348-356. doi: 10.1097/SLA.0000000000002186

Bajorat R, Porath K, Kuhn J, Elke Goßla, Doreen Goerss, Sellmann T, Köhling R, Kirschstein T. Oral administration of the casein kinase-2 inhibitor TBB leads to persistant KCa2.2 channel up-regulation in the epileptic CA1 area and cortex, but lacks anti-seizure efficacy in the pilocarpine epilepsy model. Epilepsy Research 2018; 147: 42-50.

Zechendorf E, Vaßen P, Zhang J, Hallawa A, Martincuks A, Krenkel O, Müller-Newen G, Schuerholz T, Simon TP, Marx G, Ascheid G, Schmeink A, Dartmann G, Thiemermann C, Martin L. Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning. Front Immunol. 2018; 9: 393. doi: 10.3389/fimmu.2018.00393

Gombert A, Prior I, Martin L, Grommes J, Barbati ME, Foldenauer AC, Schälte G, Marx G, Schürholz T, Greiner A, Jacobs MJ, Kalder J. Urine neutrophil gelatinase-associated lipocalin predicts outcome and renal failure in open and endovascular thoracic abdominal aortic aneurysm surgery. Sci Rep. 2018 Aug 23;8(1):12676. doi: 10.1038/s41598-018-31183-1.

Gombert A, Martin L, Foldenauer AC, Krajewski C, Greiner A, Kotelis D, Stoppe C, Marx G, Grommes J, Schuerholz T, Jacobs MJ, Kalder J. Comparison of urine and serum neutrophil gelatinase-associated lipocalin after open and endovascular thoraco-abdominal aortic surgery and their meaning as indicators of acute kidney injury. Vasa. 2018 Sep 10:1-9. doi: 10.1024/0301-1526/a000736.

2017

Gombert A, Stoppe C, Foldenauer AC, Schuerholz T, Martin L, Kalder J, Schälte G, Marx G, Jacobs M, Grommes J. Macrophage Migration Inhibitory Factor Predicts Outcome in Complex Aortic Surgery. Int J Mol Sci. 2017 Nov 9;18(11). pii: E2374. doi: 10.3390/ijms18112374.

Martin L, Derwall M, Thiemermann C, Schürholz T. [Heart in sepsis : Molecular mechanisms, diagnosis and therapy of septic cardiomyopathy]. Anaesthesist. 2017 Jul;66(7):479-490. doi: 10.1007/s00101-017-0329-x.

Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M, Thiemermann C, Schuerholz T. The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Front Immunol. 2017; 8: 681. doi: 10.3389/fimmu.2017.00681. eCollection 2017.

Bárcena-Varela S, Martínez-de-Tejada G, Martin L, Schuerholz T, Gil-Royo AG, Fukuoka S, Goldmann T, Droemann D, Correa W, Gutsmann T, Brandenburg K, Heinbockel L. Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits. Exp Mol Med. 2017; 49: e345. doi: 10.1038/emm.2017.75.

Hoeger J, Simon TP, Beeker T, Marx G, Haase H, Schuerholz T. Persistent low serum zinc is associated with recurrent sepsis in critically ill patients - A pilot study. PLoS One. 2017; 12: e0176069. doi: 10.1371/journal.pone.0176069. eCollection 2017.

Bloos F, Rüddel H, Thomas-Rüddel D, Schwarzkopf D, Pausch C, Harbarth S, Schreiber T, Gründling M, Marshall J, Simon P, Levy MM, Weiss M, Weyland A, Gerlach H, Schürholz T, Engel C, Matthäus-Krämer C, Scheer C, Bach F, Riessen R, Poidinger B, Dey K, Weiler N, Meier-Hellmann A, Häberle HH, Wöbker G, Kaisers UX, Reinhart K; MEDUSA study group. Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial. Intensive Care Med. 2017; 43: 1602-1612.  doi: 10.1007/s00134-017-4782-4.

Yamada N, Martin LB, Zechendorf E, Purvis GS, Chiazza F, Varrone B, Collino M, Shepherd J, Heinbockel L, Gutsmann T, Correa W, Brandenburg K, Marx G, Schuerholz T, Brohi K, Thiemermann C. Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Ann Surg. 2017 Mar 10. doi: 10.1097/SLA.0000000000002186. [Epub ahead of print]

Silke Seyock, Vanessa Maybeck, Emmanuel Scorsone, Lionel Rousseau, Clément Hébert, Gaëlle Lissorgues, Philippe Bergonzo, Andreas Offenhäusser. Interfacing neurons on carbon nanotubes covered with Diamond. RCS Adv., 2017; 7: 153-160 

Silke Seyock, Vanessa Maybeck, Andreas Offenhäusser. How to image cell adhesion on soft polymers?  Micron, 2017; 92: 39-42

Dmitry Kireev, Silke Seyock, Mathis Ernst, Bernhard Wolfrum, Andreas Offenhäusser. Versatile flexible graphene multielectrode Arrays. Biosensors, 2017; 7: 1.

Dmitry Kireev, Ihor Zadorozhnyi, Tianyu Qiu, Dario Sarik, Fabian Brings, Tianru Wu, Silke Seyock, Vanessa Maybeck, Martin Lottner, Benno Blaschke, José Garrido, Xiaoming Xie, Svetlana Vitusevich, Bernhard Wolfrum, Andreas Offenhäusser. Graphene field effect transistors for in vitro and ex vivo recordings. IEEE TNano, 2017; 16: 140-147. 

2016

Bajorat R, Goerss D, Brenndörfer L, Schwabe L, Köhling R, Kirschstein T. Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats. Epilepsy Behav. 2016; 57: 90-4.

Bergt S, Gruenewald M, Beltschany C, Grub A, Neumann T, Albrecht M, Vollmar B, Zacharowski K, Roesner JP, Meybohm P. The Fibrin-Derived Peptide Bβ15-42 (FX06) Ameliorates Vascular Leakage and Improves Survival and Neurocognitive Recovery: Implications From Two Animal Models of Cardiopulmonary Resuscitation. Crit Care Med. 2016; :e988-95.

Susanne Löffler, Silke Seyock, Rolf Nybom, Gunilla B. Jacobson, Agneta Richter-Dahlfors. Electrochemically triggered release of acetylcholine from scCO2 impregnated conductive polymer films evokes intracellular Ca2+ signalling in neurotypic SH-SY5Y cells.  J Controlled Release, 2016: 243: 283–290

Martin L, Horst K, Chiazza F, Oggero S, Collino M, Brandenburg K, Hildebrand F, Marx G, Thiemermann C, Schuerholz T. The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Sci Rep. 2016 Nov 17;6:37277. doi: 10.1038/srep37277. PubMed PMID: 27853260.

Keh D, Trips E, Marx G, Wirtz SP, Abduljawwad E, Bercker S, Bogatsch H, Briegel J, Engel C, Gerlach H, Goldmann A, Kuhn SO, Hüter L, Meier-Hellmann A, Nierhaus A, Kluge S, Lehmke J, Loeffler M, Oppert M, Resener K, Schädler D, Schuerholz T, Simon P, Weiler N, Weyland A, Reinhart K, Brunkhorst FM; SepNet–Critical Care Trials Group.. Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial. JAMA. 2016 Nov 1;316(17):1775-1785. doi: 10.1001/jama.2016.14799. PubMed PMID: 27695824.

Martin L, Koczera P, Zechendorf E, Schuerholz T. The Endothelial Glycocalyx: New Diagnostic and Therapeutic Approaches in Sepsis. Biomed Res Int. 2016;2016:3758278. Review. PubMed PMID: 27699168; PubMed Central PMCID: PMC5028820.

Martin L, Peters C, Heinbockel L, Moellmann J, Martincuks A, Brandenburg K, Lehrke M, Müller-Newen G, Marx G, Schuerholz T. The synthetic antimicrobial peptide 19-2.5 attenuates mitochondrial dysfunction in cardiomyocytes stimulated with human sepsis serum. Innate Immun. 2016 Sep 13. pii: 1753425916667474. [Epub ahead of print] PubMed PMID: 27624711.

Koczera P, Martin L, Marx G, Schuerholz T. The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity. Int J Mol Sci. 2016 Aug 5;17(8). pii: E1278. doi: 10.3390/ijms17081278. Review. PubMed PMID: 27527162; PubMed Central PMCID: PMC5000675.

Martin L, Koczera P, Simons N, Zechendorf E, Hoeger J, Marx G, Schuerholz T. The Human Host Defense Ribonucleases 1, 3 and 7 Are Elevated in Patients with Sepsis after Major Surgery--A Pilot Study. Int J Mol Sci. 2016 Feb 26;17(3):294. doi: 10.3390/ijms17030294. PubMed PMID: 26927088; PubMed Central PMCID: PMC4813158.

Schuerholz T, Simon TP, Marx G. Investigating colloids and crystalloids--everything clear? Br J Anaesth. 2016 Apr;116(4):453-5. doi: 10.1093/bja/aev542. PubMed PMID: 26873176.

Patejdl R, Winkelmann A, Ehler J, Zettl H, Meister S, Zettl UK. Diagnostic workup and treatment of antibody-related encephalomyelitis. Fortschr Neurol Psychiatr 2016 Oct;84(S02): S88-S91.

2015

Stevanovic A, Schmitz S, Rossaint R, Schürholz T, Coburn M. CONSORT item  reporting quality in the top ten ranked journals of critical care medicine in 2011: a retrospective analysis. PLoS One. 2015 May 28;10(5):e0128061. doi: 10.1371/journal.pone.0128061. PubMed PMID: 26020246; PubMed Central PMCID: PMC4447424.

Ekaney ML, Bockmeyer CL, Sossdorf M, Reuken PA, Conradi F, Schuerholz T, Blaess MF, Friedman SL, Lösche W, Bauer M, Claus RA. Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C. Mol Med. 2015 Apr 3;21:355-63. doi: 10.2119/molmed.2014.00202. PubMed PMID: 25860876; PubMed Central PMCID: PMC4534472.

Hoeger J, Simon TP, Doemming S, Thiele C, Marx G, Schuerholz T, Haase H. Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis. Biometals. 2015 Aug;28(4):693-700. doi:10.1007/s10534-015-9858-4. PubMed PMID: 25940830.

Simon TP, Thiele C, Schuerholz T, Fries M, Stadermann F, Haase G, Amann KU, Marx G. Molecular weight and molar substitution are more important in HES-induced renal impairment than concentration after hemorrhagic and septic shock. Minerva Anestesiol. 2015 Jun;81(6):608-18. PubMed PMID: 25296880.

Thomas-Rueddel DO, Poidinger B, Weiss M, Bach F, Dey K, Häberle H, Kaisers U, Rüddel H, Schädler D, Scheer C, Schreiber T, Schürholz T, Simon P, Sommerer A, Schwarzkopf D, Weyland A, Wöbker G, Reinhart K, Bloos F; Medical Education for Sepsis Source Control and Antibiotics Study Group.. Hyperlactatemia is an independent predictor of mortality and denotes distinct subtypes of severe sepsis and septic shock. J Crit Care. 2015 Apr;30(2):439.e1-6. doi:10.1016/j.jcrc.2014.10.027. PubMed PMID: 25466313.

Schürholz T. [Sepsis and multiple organfailure--potential therapeutic interventions]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2015 Feb;50(2):132-40. doi: 10.1055/s-0041-100302. Review. German. PubMed PMID: 25723608.

Meybohm P, Lindau S, Schürholz T, Larmann J, Stehr SN, Nau C. [Tools for junior scientists support from medical societies: survey amongst members organized in the Association of the Scientific Medical Societies (AWMF)]. Z Evid Fortbild Qual Gesundhwes. 2015;109(8):632-41. doi: .1016/j.zefq.2015.06.002. German. PubMed PMID: 26704825.

Martin L, De Santis R, Koczera P, Simons N, Haase H, Heinbockel L, Brandenburg K, Marx G, Schuerholz T. The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis. PLoS One. 2015 Nov 23;10(11):e0143583. doi: 10.1371/journal.pone.0143583. PubMed PMID: 26600070; PubMed Central PMCID: PMC4658182.

Martin L, Peters C, Schmitz S, Moellmann J, Martincuks A, Heussen N, Lehrke M, Müller-Newen G, Marx G, Schuerholz T. Soluble Heparan Sulfate in Serum of Septic Shock Patients Induces Mitochondrial Dysfunction in Murine Cardiomyocytes. Shock. 2015 Dec;44(6):569-77. PubMed PMID:26529654.

Martinez de Tejada G, Heinbockel L, Ferrer-Espada R, Heine H, Alexander C, Bárcena-Varela S, Goldmann T, Correa W, Wiesmüller KH, Gisch N, Sánchez-Gómez S, Fukuoka S, Schürholz T, Gutsmann T, Brandenburg K. Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides. Sci Rep. 2015 Sep 22;5:14292. doi: 10.1038/srep14292. PubMed PMID: 26390973; PubMed Central PMCID: PMC4585737.

Martin L, van Meegern A, Doemming S, Schuerholz T. Antimicrobial Peptides in Human Sepsis. Front Immunol. 2015 Aug 20;6:404. doi: 10.3389/fimmu.2015.00404. Review. PubMed PMID: 26347737; PubMed Central PMCID: PMC4542572.

Hildebrand F, Pape HC, Horst K, Andruszkow H, Kobbe P, Simon TP, Marx G, Schürholz T. Impact of age on the clinical outcomes of major trauma. Eur J Trauma Emerg Surg. 2016 Jun;42(3):317-32. doi: 10.1007/s00068-015-0557-1. Review. PubMed PMID: 26253883.

Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T, Gutsmann T, Mier W, Schürholz T, Drömann D, Brandenburg K, Martinez de Tejada G. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. PLoS One. 2015 Jul 21;10(7):e0133291. doi: 10.1371/journal.pone.0133291. PubMed PMID: 26197109; PubMed Central PMCID: PMC4510266.

Martin L, Schmitz S, De Santis R, Doemming S, Haase H, Hoeger J, Heinbockel L, Brandenburg K, Marx G, Schuerholz T. Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum. PLoS One. 2015 May 29;10(5):e0127584. doi: 10.1371/journal.pone.0127584. PubMed PMID: 26024383; PubMed Central PMCID: PMC4449035.

2014

Ehler J, Koball S, Sauer M, Hickstein H, Mitzner S, Benecke R, Zettl UK. Therapeutic Plasma  Exchange in Glucocorticosteroid-Unresponsive Patients With Clinically Isolated Syndrome. Ther Apher Dial 2014; 18: 489-96.

2013 und früher

Bergt S, Wagner NM, Heidrich M, Butschkau A, Nöldge-Schomburg GE, Vollmar B, Roesner JP (2013): Hydrocortisone reduces the beneficial effects of toll-like receptor 2 deficiency on survival in a mouse model of polymicrobial sepsis. Shock 40(5):414-9.

Wagner NM, Bierhansl L, Butschkau A, Noeldge-Schomburg G, Roesner JP, Vollmar B (2013): TLR2-deficiency of cKit+ bone marrow cells is associated with augmented potency to stimulate angiogenic processes. Int J Clin Exp Pathol 6(12):2813-23.

Bergt S, Güter A, Grub A, Wagner NM, Beltschany C, Langner S, Wree A, Hildebrandt S, Nöldge-Schomburg G, Vollmar B, Roesner JP (2013): Impact of Toll-like receptor 2 deficiency on survival and neurological function after cardiac arrest: a murine model of cardiopulmonary resuscitation. PLoS One 8(9):e74944.

Wagner NM, Bierhansl L, Nöldge-Schomburg G, Vollmar B, Roesner JP (2013): Toll-like receptor 2-blocking antibodies promote angiogenesis and induce ERK1/2 and AKT signaling via CXCR4 in endothelial cells. Arterioscler Thromb Vasc Biol 33(8):1943-51.

Bajorat R, Wilde M, Sellmann T, Kirschstein T, Köhling R (2011): Seizure frequency in pilocarpine-treated rats is is independent of circadian rhythm. Epilepsia 52(9): e118-e122.

Roesner JP, Mersmann J, Bergt S, Bohnenberg K, Barthuber C, Szabo C, Nöldge-Schomburg GE, Zacharowski K (2010): Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. Shock 33(5):507-12.

Menzebach A, Bergt S, von Waldthausen P, Dinu C, Nöldge-Schomburg G, Vollmar B (2010): A comprehensive study of survival, tissue damage, and neurological dysfunction in a murine model of cardiopulmonary resuscitation after potassium-induced cardiac arrest. Shock 33(2):189-96.

Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Vagts DA, Scheeren TW, Vollmar B, Nöldge-Schomburg GE, Zacharowski K (2009): Bbeta15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion. Crit Care Med 37(2):598-605.

Roesner JP, Koch A, Bateman R, Scheeren TW, Zander R, Nöldge-Schomburg GE, Zacharowski K (2009): Accurate and continuous measurement of oxygen deficit during haemorrhage in pigs. Resuscitation 80(2):259-63.

Kirschstein T, Rehberg M, Bajorat R, Tokay T, Porath K, Köhling R (2009): High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscle. Acta Pharmacol Sin. 30(8):1123-31.

Roesner JP, Petzelbauer P, Koch A, Mersmann J, Zacharowski PA, Boehm O, Reingruber S, Pasteiner W, Mascher D, Wolzt M, Barthuber C, Nöldge-Schomburg GE, Scheeren TW, Zacharowski K (2007): The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury. Crit Care Med 35(7):1730-5.

Roesner JP, Vagts DA, Iber T, Eipel C, Vollmar B, Nöldge-Schomburg GF (2006): Protective effects of PARP inhibition on liver microcirculation and function after haemorrhagic shock and resuscitation in male rats. Intensive Care Med 32(10):1649-57.

Bajorat R, Bräuer AU, Wasner U, Rolfs A, Strauss U (2005): Functional significance of HCN2/3-mediated Ih in striatal cells at early developmental stages. J Neurosci Res 82(2):206-13.

Vagts DA1, Iber T, Roesner JP, Mutz C, Kurzweg V, Harkner C, Brüderlein K, Nöldge-Schomburg GF (2005): Effects of systemically applied clonidine on intestinal perfusion and oxygenation in healthy pigs during general anaesthesia and laparotomy. Eur J Anaesthesiol 22(11):879-86.

Strauss U, Herbrik M, Mix E, Bajorat R, Jung S, Gimsa U, Rolfs A (2005): Dopamine exerts no acute effects on Kv1.3 in activated encephalitogenic T cells. Neuroimmunomodulation 12:45-53.

Vagts DA1, Hecker K, Iber T, Roesner JP, Spee A, Otto B, Rossaint R, Nöldge-Schomburg GF (2004): Effects of xenon anaesthesia on intestinal oxygenation in acutely instrumented pigs. Br J Anaesth 93(6):833-41.

Strauss U, Kole MHP, Bräuer AU, Pahnke J, Bajorat R, Rolfs A, Nitsch R, Deisz RA (2004): An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy. Eur J Neurosci 19:3348-58.

Benz S, Bergt S, Obermaier R, Wiessner R, Pfeffer F, Schareck W, Hopt UT (2001): Impairment of microcirculation in the early reperfusion period predicts the degree of graft pancreatitis in clinical pancreas transplantation. Transplantation 71(6):759-63.